I have been using gear for about 6 cycles now. I have tried sust350 and test400. I decided to try the new hexl450 as I liked the spread of esters. The results are FANTASTIC! The best I’ve had with mixed esters by far. BUT…….and I am sad to say, with a large price. The PIP is almost unbearable with this stuff. I’ve tried warming it, massaging the area, changing vials, needle changes, slower injections, different injection sites, different positions, anything else you can think of I’ve done. This stuff just plain hurts. There is no way around it. Your injection site will be in pain for days or weeks after the injection. If you can deal with it, it’s the best stuff out there, if you cannot deal with pain, stay clear.