For me Anadroxyl didn’t kick start til about my last three weeks in from a 6 week cycle and by then I wanted to go even longer because the pumps was great intense with an increase in strength. It pushes you to drive hard but it’s mandatory to discipline yourself cause it’s hard on your insides and I felt that as well. As long as you respect your cut-off time, your good. Most people use it in the beginning of their cycle but I take it in the end of my cycle. GOOD STUFF.